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SC10: Molecular Imaging of the Blood-Brain Barrier
Tuesday, June 14 | 3:30 - 6:30 pm


In this short course, we will discuss the development and application of molecular imaging techniques for brain research. The course will include introduction of molecular imaging, how to design chemical probes to cross the blood-brain barrier for neuroimaging, the application of novel and existing neuroimaging tools for brain research, and CNS drug discovery.

  • An overview various brain imaging techniques such as stimulus- or task-related BOLD fMRI, resting state fMRI, arterial spin labeling, structural imaging, diffusion, spectroscopy
  • How these techniques contribute to understanding various pathophysiological elements of pathological states
  • Case studies of chronic pain to demonstrate the application of brain imaging to clinical pathology
  • An overview of the capabilities and roles of neuroimaging technologies in studies of BBB functions but also drug PK/PD and CNS effects
  • Examples of optical, MRI, and PET imaging applications, especially analysis of the brain and molecular exchanges across the BBB in the local environment for effective treatment

3:30 Introduction

Changning Wang, Ph.D., Instructor, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School

3:40 Using Multimodal Brain Imaging to Image Pathology: The Case of Chronic Pain

Mark_LoggiaMarco L. Loggia, Ph.D., Assistant Professor, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School

In this presentation, I will provide an overview of how various brain imaging techniques (stimulus- or task-related BOLD fMRI, resting state fMRI, arterial spin labeling, structural imaging, diffusion, spectroscopy, etc.) contribute to understanding various pathophysiological elements of pathological states. Given my own scientific interests, I will use examples from literature on the study of chronic pain to demonstrate the application of brain imaging to clinical pathology.

4:30 Neuroimaging for Blood-Brain Barrier Studies in the Biopharmaceutical Industry

Xiayou_YingXiaoyou Ying, Ph.D., Head of Bioimaging, Sanofi DSAR US

The blood-brain barrier (BBB) remains one of the greatest challenges for delivery of therapeutic agents to diseased CNS regions. Neuroimaging technologies could enable us to visualize and measure not only BBB functions but also drug PK/PD and CNS effects. This talk will provide an overview of the capabilities and roles of neuroimaging technologies in such studies, with examples of optical, MRI and PET imaging applications, especially analysis of the brain and molecular exchanges across the BBB in the local environment for effective treatment.

5:20 Coffee Break

5:40 Molecular Imaging in Brain Research

Changing_WangChangning Wang, Ph.D., Instructor, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School

In this presentation, I will discuss the development and application of molecular imaging techniques for brain research. The topic will include how to design chemical probes to across the blood-brain-barrier for neuroimaging; the application of novel and existing neuroimaging tools for brain research and CNS drug discovery.

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