New Approaches for Predicting Drug Toxicity

Adverse drug events such as cardiotoxicity, hepatotoxicity and other organ toxicities keep surfacing in the clinic, and idiosyncratic drug toxicity continues to haunt the drug development process. So what are scientists and clinicians doing to make sure that compounds fail early and cheaply? New screening technologies such as in vitro assays and in vivo models continue to be developed, but are the right tools being used at the right time to predict and detect adverse events? Cambridge Healthtech Institute’s ninth annual conference on New Approaches for Predicting Drug Toxicity looks at the scientific and technological progress being made to better predict drug-related toxicities at the preclinical stage, and avoid unexpected and costly findings in the clinic. What assays and models are being used, how reliable and predictable is the data, and how is this information impacting decisions before compounds are tested in patients? Hear experiences shared by experts and join the interactive sessions and panel discussions on issues related to drug toxicity for active networking, brainstorming and collaborating.

Who should attend: Drug discovery scientists, high-throughput screeners, cell biologists, safety pharmacologists, toxicologists, stem cell biologists, scientists in lead optimization and ADME/DMPK groups.

Topics will include, but are not limited to:

  • New screening technologies: Organs-on-chips, iPSC and 3D cell-based assays, humanized animal models
  • Evaluating target-based drug toxicity
  • Identifying structural drivers of toxicity
  • Integrating lead optimization and risk assessment strategies
  • Role of drug metabolites and drug transporters
  • Leveraging new in silico tools for early safety predictions
  • Translational aspects of preclinical safety assessments
  • Update on initiatives launched by safety organizations & consortia
  • Understanding how the microbiome impacts drug toxicity

If you would like to submit a proposal to give a presentation at this meeting, please click here.

The deadline for submission is November 9, 2015.

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program. Please note that due to limited speaking slots, preference is given to pharmaceutical and biotech companies, regulators and those from academia. Additionally, vendors/consultants who provide products and services to these biopharmaceutical companies are offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

For questions or suggestions about the meeting, please contact:
Tanuja Koppal, Ph.D.
Conference Director
Cambridge Healthtech Institute
T: (+1) 973-525-4667

For sponsorship and exhibit sales information including sponsored podium presentations, contact:
Joseph Vacca
Associate Director, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-5431




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